Exfoliative Keratolysis


Exfoliative keratolysis is a rare genetic skin disorder characterized by abnormal peeling of the outermost layer of the skin, the stratum corneum. The exact cause of this condition is not fully understood, but it is generally believed to result from genetic mutations that weaken the adhesion between skin cells(sources from therapeutique-dermatologique.org).

In normal circumstances, keratinocytes are interconnected through structures known as desmosomes, forming a tight barrier. In individuals with exfoliative keratolysis, genetic mutations damage these desmosomal structures, preventing proper adhesion of cells in the stratum corneum. This leads to a loosening of the stratum corneum, making it prone to peeling.

Exfoliative keratolysis can be hereditary, resulting from specific genetic mutations. These mutations may occur spontaneously or be transmitted through familial inheritance. However, the precise mutated genes are not yet fully understood.

Additionally, exfoliative keratolysis may be associated with other genetic or diseases, such as genetic skin disorders or immune system dysregulation. These conditions can affect the normal function of keratinocytes, leading to the abnormal peeling of the stratum corneum(quotes from therapeutique).

In summary, exfoliative keratolysis is a rare skin disorder caused by genetic mutations, resulting in the abnormal peeling of the outermost layer of the skin. The specific reasons behind this condition are not completely clear, but genetic mutations and other hereditary or disease-related factors may play a role.

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